This review compiles preclinical evidence that hyaluronic acid (HA)–based biomaterials modulate neuroinflammation, autophagic flux, α‑synuclein propagation, and ECM remodeling while enabling targeted drug/gene delivery and scaffolded cell transplantation in Alzheimer's and Parkinson's disease.

Review synthesizing PD molecular mechanisms—α-synuclein, mitochondrial dysfunction, neuroinflammation, impaired autophagy, sirtuins and insulin/incretin signaling—and evaluating phytochemicals (resveratrol, curcumin, quercetin, baicalein, berberine, EGCG) and incretin mimetics as multi-target…

This review summarizes evidence that lipid droplets modulate neuronal lipid metabolism, oxidative stress, inflammation, and interact with α-synuclein, and proposes targeting LD dynamics (e.g., lipophagy or LD-associated proteins) as therapeutic strategies for neurodegenerative diseases including…

Narrative review synthesizing preclinical and clinical evidence that gut microbiota perturbations alter brain function through neural (vagus), immune (cytokine/neuroinflammation), and metabolic (SCFAs, TMAO, tryptophan derivatives) pathways and noting associations between dysbiosis and…

Comprehensive review detailing how long non-coding RNAs regulate key neurodegenerative processes (protein aggregation, neuroinflammation, mitochondrial dysfunction, LLPS, exosome signaling), their detectability as liquid-biopsy biomarkers, and therapeutic targeting strategies (ASOs, gene editing,…

Narrative review proposing that neurosyphilis can produce Parkinsonism via shared mechanisms—BBB disruption, dopaminergic neuronal loss, TLR-driven neuroinflammation—and summarizes diagnostic approaches and potential therapeutic repurposing (β-lactams, doxycycline) and nanoparticle-based…

This review details how soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxy fatty acids, summarizes urea- and amide-based sEH inhibitor chemistry and PK, and presents preclinical and early clinical evidence that sEH inhibition can reduce neuroinflammation and provide neuroprotection…

This review synthesizes evidence that CNPY2, an ER-luminal regulator of UPR, mitochondrial dynamics, oxidative stress, and apoptosis, has neuroprotective roles in Parkinson's and Huntington's disease and discusses its therapeutic potential across cancer, cardiovascular, and neurodegenerative…

Narrative review compiling preclinical and clinical evidence that combining exercise-based physiotherapy with pharmacological treatments in Parkinson's disease can enhance neuroprotection—via increased BDNF, reduced oxidative stress and inflammation, and improved motor/non-motor outcomes—while…

Integrated plasma metabolomics, proteomics, and gut metagenomics reveal that RBD-associated PD and idiopathic RBD show a shift from TCA toward glycolysis, dysregulated urea cycle, lipid remodeling, activation of PI3K‑Akt/IL‑17/NF‑κB/MAPK/TNF inflammatory pathways, and accumulation of gut…

This review synthesizes evidence that redox- and modification-dependent extracellular HMGB1 drives neuroinflammation via TLR4/RAGE/CXCR4 and downstream NF-κB/MAPK/JAK-STAT/inflammasome pathways, links HMGB1 dysregulation to Parkinson's disease among other CNS disorders, and summarizes preclinical…

This review proposes that dynamic instability of neuronal lysosomal pH—driven by components such as V-ATPase, TMEM175, SLC7A11, ClC-7 and regulated by AMPK–mTORC1–TFEB—is a pathogenic mechanism in neurodegeneration and outlines strategies to restore lysosomal pH homeostatic resilience as a…

This review synthesizes evidence that selected vitamins influence oxidative stress, inflammation, protein aggregation, neurotransmitter synthesis, and mitochondrial function—and may synergize with coenzyme Q10 to provide neuroprotective benefits across neurodegenerative diseases, including…

Combining MPTP mouse experiments and GEO-based bioinformatics, the paper shows ACE2 deficiency worsens dopaminergic neuron loss, α-synuclein–linked neuroinflammation and lung fibrosis via downregulated FoxO1 and upregulated TNF, JAK1-STAT3 and AGE-RAGE pathways, and it nominates diagnostic hub…

Peripheral microcurrent stimulation improved motor behavior and preserved substantia nigra dopaminergic neurons in MPTP-treated mice, associated with reduced α-synuclein accumulation and downregulation of TLR4, PARP, and cleaved caspase-3.

3-monothiopomalidomide (3MP), a novel thalidomide derivative, reduces α-synuclein aggregation, suppresses microglial inflammatory responses, preserves SNpc dopaminergic neurons, and improves motor and cognitive outcomes in cell and rat α-synuclein oligomer models, outperforming pomalidomide.

In an LPS-induced rat model of Parkinsonism, isotopically enriched 64Zn-aspartate reduced behavioral deficits and apomorphine rotations, normalized systemic inflammatory indices and CRP, shifted circulating and peritoneal phagocytes toward anti-inflammatory phenotypes, partially restored thymus…

ZPT01, a three‑herb formulation, improved motor behavior and protected dopaminergic neurons in MPTP mice and, supported by docking and cell experiments, appears to act via restoring AKT phosphorylation and suppressing COX‑2/PTGS2‑mediated neuroinflammation.

This in silico study uses network pharmacology, molecular docking, 100-ns MD simulations, and DFT to nominate quercetin and kaempferol from the Tianma-Gouteng herb pair as stable binders of AKT1, TP53, and STAT3, linking PI3K-AKT signaling, mitochondrial apoptosis, and neuroinflammation to…

Integrative bulk and single-cell transcriptomics identified 77 shared DEGs between COVID-19 and Parkinson's disease, with enrichment of neuroinflammatory pathways and a marked increase of CHI3L1-expressing astrocytes and enhanced astrocyte–microglia/neuron signaling.