Loneliness predicts worse Parkinsonism: a longitudinal, community-based, clinical-pathological study.
AI interpretation is pending for this paper.
What the AI sees
Not AI summarized yet.
Research significance
Pending deeper interpretation.
Source abstract
Loneliness is increasingly acknowledged as important in parkinsonism-related disorders. However, little is known about reciprocal longitudinal relationships between loneliness and parkinsonism. In this study, 3,099 community-based individuals (Mage=78.09, 75.2% women) completed measures of loneliness, isolation, depression and were rated on parkinsonism severity annually with 846 having available postmortem data. Controlling for demographic and social-emotional covariates, mixed multilevel modeling evaluated longitudinal impacts of parkinsonism on loneliness and loneliness on parkinsonism. The loneliness→parkinsonism models explained greater variance, with loneliness associated with worse parkinsonism and greater rates of motor decline. Whereas parkinsonism→loneliness models revealed worse parkinsonism associated with worse loneliness, parkinsonism did not predict rate of loneliness change. Subjects with Lewy Bodies at autopsy had worse loneliness proximate to death and a more pronounced time×loneliness interaction compared to those without. There are bidirectional relationships between loneliness and parkinsonism, with loneliness being the more potent longitudinal predictor.