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RESEARCH PAPER ANALYSIS

Stigma and social symptoms in Parkinson's disease: A scoping review.

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PMID42170062
JournalClinical parkinsonism & related disorders
Publication Date2026-01-01
Ingested2026-05-22 06:55 AM
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ABSTRACT

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BACKGROUND: The incidence of Parkinson's disease (PD) is increasing more rapidly than any other neurodegenerative disorder. Motor and non-motor symptoms, and deficits in cognition and communication, negatively impact people with PD's social functioning and can result in enacted and felt stigma. The aim of this scoping review is to explore the determinants and effects of stigma in PD. METHODS: This scoping review followed the Joanna Briggs Institute methodology for scoping reviews. Quantitative and qualitative studies from January 2000 to April 2026 focusing on stigma in PD were considered for inclusion. Databases included Medline via OVID, PsychInfo and Scopus. RESULTS: From 334 screened articles, 25 papers were finally included. Most papers found depression to be a determinant of enacted and felt stigma. Some papers found motor symptoms, younger age, difficulty with activities of daily living, and severe PD to be predictive of stigma. Facial masking, abnormal bodily movement, and speech impairment were linked to felt stigma and to stigmatising attitudes from the general public and clinical practitioners alike. DISCUSSION: Stigmatising views have damaging consequences for people with PD. Negative outcomes of stigma include greater difficulties in the social and emotional spheres, and social avoidance and isolation. More awareness and education for the public, but also healthcare providers, are needed to address negative attitudes and bias towards people with PD. There needs to be more research into interventions to reduce felt stigma, such as psychological training or peer support.

SUPPORTING PAPER SET

32 more papers to review

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B, Biointerfaces 86.0 13 Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases. Experimental physiology 84.0 14 Flavonoid Rutin Reduces Intestinal Inflammation in an Experimental Model of Parkinson's Disease. Neurotoxicity research 70.0 15 Nanostructured Lipid Carriers Enhance Brain Delivery and Antioxidant Efficacy of a Small-Molecule MAO B Inhibitor for Neurodegenerative Disease Therapy. Molecular pharmaceutics 78.0 16 Pathophysiological Role of the Gut Brain Axis in Parkinson's Disease: From Microbial Metabolites and Intestinal Permeability to Central Neuroinflammation. Current neurovascular research 86.0 17 Parkinson's Disease: From Metabolism to Genetics-A Comprehensive Review. Current issues in molecular biology 86.0 18 Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders. Neuroprotection (Chichester, England) 76.0 19 Integrative network pharmacology delineates dual GPCR and non-GPCR mechanisms of blended and individual Taikong Blue lavender and Pingyin rose essential oils in neurodegenerative and psychiatric disorders. Computers in biology and medicine 65.0 20 Models of neuroprotection in Parkinson's disease: Exploring cellular, molecular, and microenvironmental targets. Experimental neurology 78.0 21 Hyaluronic acid: emerging roles and biomaterial innovations in Alzheimer's and Parkinson's disease therapy. Frontiers in pharmacology 75.2 22 Molecular mechanisms underlying Parkinson's disease and role of phytochemicals, α-synuclein, sirtuins, and incretin mimetics in potential therapy. Frontiers in pharmacology 75.0 23 Lipid droplets in neurodegenerative diseases: pathological drivers and therapeutic vulnerabilities. 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Central nervous system agents in medicinal chemistry 64.0 30 Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder. Signal transduction and targeted therapy 84.0 31 HMGB1-mediated neuroinflammation: molecular mechanisms and emerging therapeutic approaches. Inflammopharmacology 78.0 32 Beyond acid-base dyshomeostasis: Dynamic instability of neuronal lysosomal pH as a pathogenic mechanism and therapeutic target in neurological diseases. Biochemical pharmacology 88.0
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